glutathione transferase function S-transferase Frontiers | Glutathione S-Transferases: Role

Several compounds from garlic , including ajoene (Hattori 2001), diallyl disulfide (Zhao 1998), S-allylmercaptocysteine (Sumioka 2001), and fresh garlic homogenates (Wang 1996) have been shown to preserve liver glutathione levels as well as reduce serum markers of liver damage, liver tissue death, and animal mortality in rodent models of acetaminophen overdose when supplied in sufficient quantities (up to 5 g/kg for fresh garlic homogenates)

All of these tie into health and longevity and health span in preventing chronic disease

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For instance, studies have demonstrated that sorafenib treatment leads to a significant enhancement in glucose uptake and lactate production, which is attributed to the overexpression of key glycolytic enzymes (85)

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In addition, superoxide anions will react with nitric oxide (NO) to produce peroxynitrite (ONOO ), which causes nitrosative stress